Tables for
Volume F
Crystallography of biological macromolecules
Edited by E. Arnold, D. M. Himmel and M. G. Rossmann

International Tables for Crystallography (2012). Vol. F, ch. 14.1, p. 372   | 1 | 2 |


B. W. Matthewsa*

aInstitute of Molecular Biology, Howard Hughes Medical Institute and Department of Physics, University of Oregon, Eugene, OR 97403, USA
Correspondence e-mail:


The consequences of using the incorrect hand for the heavy-atom arrangement in phase determination. The correct heavy-atom arrangement gives the construction drawn in solid lines with ϕ uniquely determined as the correct phase for [{\bf F}_{P}]. If the enantiomeric arrangement of heavy atoms is used, the dashed construction will result, leading to the incorrect phase [\varphi^\prime]. Even though ϕ is correct and [\varphi^\prime] is incorrect, both phase determinations have an identical figure of merit.