Tables for
Volume F
Crystallography of biological macromolecules
Edited by E. Arnold, D. M. Himmel and M. G. Rossmann

International Tables for Crystallography (2012). Vol. F, ch. 14.1, p. 368   | 1 | 2 |


B. W. Matthewsa*

aInstitute of Molecular Biology, Howard Hughes Medical Institute and Department of Physics, University of Oregon, Eugene, OR 97403, USA
Correspondence e-mail:


(a) Harker construction for a double isomorphous replacement. [\varphi_{M}] is the `most probable' phase for [{\bf F}_{P}]. (b) Phase probability distribution corresponding to the double isomorphous replacement shown in part (a). The curve for derivative 1 is solid, that for derivative 2 is dashed, and that for the combined distribution is drawn as a dotted-and-dashed line.