International
Tables for
Crystallography
Volume F
Crystallography of biological macromolecules
Edited by E. Arnold, D. M. Himmel and M. G. Rossmann

International Tables for Crystallography (2012). Vol. F, ch. 4.3, p. 133   | 1 | 2 |

Figure 4.3.6.1 

Z. S. Derewendaa*

aDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908–0736, USA
Correspondence e-mail: zsd4n@virginia.edu

[Figure 4.3.6.1]
Figure 4.3.6.1

Phage-display-generated Fab fragments as crystallization chaperones: the structure of the KcsA channel in the closed conformation in complex with a synthetic Fab (PDB code 3eff ; Uysal et al., 2009[link]). (a) A diagram showing how the Fab binds to the cytosolic portion in reference to the transmembrane domain. (b) The crystal structure of the complex showing how the synthetic Fab molecules mediate the major crystal contacts. (Figure courtesy of Dr Anthony Kossiakoff, University of Chicago.)