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Objectives
Ten Eyck, L. F. and Watenpaugh, K. D.  International Tables for Crystallography (2012). Vol. F, Section 18.1.3, p. 459 [ doi:10.1107/97809553602060000855 ]
Objectives 18.1.3. Objectives A variety of methods are employed to improve the agreement between observed and calculated macromolecular diffraction patterns. Some of the more popular methods are discussed in the different sections of this chapter. In part, the different methods arise from focusing on different goals during different stages of model ...

Background
Ten Eyck, L. F. and Watenpaugh, K. D.  International Tables for Crystallography (2012). Vol. F, Section 18.1.2, p. 459 [ doi:10.1107/97809553602060000855 ]
... the next electron-density map, but this was not done. Watenpaugh et al. (1972) first showed in 1971 that [Delta]F ... from initial MIR or SIR (single isomorphous replacement) experimental phases. Watenpaugh et al. (1973) also applied least-squares techniques to the ... be the last word on the subject. References Adams, P. D., Pannu, N. S., Read, R. J. & Brunger, A. T. ( ...

Overview
Ten Eyck, L. F. and Watenpaugh, K. D.  International Tables for Crystallography (2012). Vol. F, Section 18.1.1, p. 459 [ doi:10.1107/97809553602060000855 ]
Overview 18.1.1. Overview Methods of improving and assessing the accuracy of the positions of atoms in crystals rely on the agreement between the observed and calculated diffraction data. Calculation of diffraction data from an atomic model depends on the theoretical model of scattering of X-rays by crystals discussed in IT ...

Conclusion
Ten Eyck, L. F. and Watenpaugh, K. D.  International Tables for Crystallography (2012). Vol. F, Section 18.1.10, p. 464 [ doi:10.1107/97809553602060000855 ]
Conclusion 18.1.10. Conclusion It is always important to bear in mind that macromolecular crystal structures are models intended to explain a particular set of observations. Statistical measures can determine how well the model explains the observations, but cannot say whether the model is true or not. The distinction between precision and ...

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