International Tables for Crystallography

Electron cryomicroscopy of biological macromolecules
T. S. Baker and R. Henderson. International Tables for Crystallography (2012). Vol. F, ch. 19.6, pp. 593-614  [ doi:10.1107/97809553602060000872 ]


This chapter gives a complete but concise introduction to electron cryomicroscopy. The theoretical and practical background is discussed together with a review of applications to the three-dimensional structural analysis of biological macromolecules or macromolecular assemblies. It includes basic descriptions of how to analyse the structures of molecules arranged in the form of two-dimensional crystals, helical arrays or as single particles with or without symmetry. The chapter concludes by anticipating trends towards increased automation, development of better electronic cameras and increasing use of electron tomography for analysis of cell structure.

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About International Tables for Crystallography

International Tables for Crystallography is the definitive resource and reference work for crystallography. The series consists of nine volumes and comprises articles and tables of data relevant to crystallographic research and to applications of crystallographic methods in all sciences concerned with the structure and properties of materials.